LINKBetaseron (Interferon beta-1b) is a purified, sterile, lyophilized protein product produced by recombinant DNA techniques and formulated for use by injection.

Interferon beta-1b is manufactured by bacterial fermentation of a strain of Escherichia coli that contains the gene for human interferon betaser17.


Betaseron is indicated for use in patients with relapsing-remitting multiple sclerosis to reduce the frequency of clinical exacerbations.

Relapsing-remitting MS is characterized by recurrent attacks of neurologic dysfunction followed by complete or incomplete recovery.

The safety and efficacy of Betaseron in chronic-progressive MS has not been evaluated.

Betaseron is contraindicated in patients with a history of hypersensitivity to natural or recombinant interferon beta, Albumin Human USP, or any other component of the formulation.

Injection site reactions are common.

They include redness, pain and swelling, and discoloration. Less frequently, injection site necrosis (skin breakdown and tissue destruction) has been observed.

To minimize chances for a reaction, you should rotate injection sites as recommended by your physician.

Do not make an injection into skin that is tender, red, or hard.

If you experience a break in the skin or drainage of fluid from the injection site, you should promptly contact your physician before continuing injections with Betaseron.

Flu-like symptoms are also common. They include fever, chills, sweating, fatigue, and muscle aches.

Taking Betaseron at night may help lessen the impact of flu-like symptoms.

Depression, including suicide attempts, has been reported by patients. If you experience such symptoms, contact your physician promptly.