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Timothy L. Vollmer, MD
Department of Neurology
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Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
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Weill Medical College of Cornell University

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Medicine Damaged My
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MS put me out of work:
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Migranes + MS =
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I've Had 47 Surgeries
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The Monster is Attacking
Me Again! I'm Taking
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How To Reduce The Side
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Before MS, I spent
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I checked in to the
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My Neuro Wants
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This Is My 1st Column, It's About Being In A Trial For Alemtuzumab (Campath)
This Pill Got Rid of
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My Relationship With
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By 4 Weeks I Gained
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Timothy L. Vollmer M.D.
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University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
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Sunday

 

STUDY...Predictors of long-term clinical response to interferon beta therapy in relapsing multiple sclerosis.

OBJECTIVES: The aim of this study was to identify clinical, magnetic resonance imaging (MRI) and biological markers predictive of long-term clinical response to interferon beta (IFN beta) therapy in patients with relapsing-remitting multiple sclerosis (RRMS).METHODS: Sixty-eight patients treated with IFN beta were followed over a 6-year period. Relapse rate and disability progression were evaluated throughout the study. We considered suboptimal clinical response to be either the presence of sustained disability progression, or more than two relapses. Baseline and 12-month demographic, clinical and MRI findings, as well as the development of neutralizing antibodies (NAbs) against IFN beta during the first year of therapy were analyzed as predictors of long-term clinical outcome..CONCLUSIONS: Variables assessable within the first year of treatment significantly influence relapse rate and disability progression in patients with RRMS treated with IFN beta. These findings may help clinicians to make decisions regarding therapy regimen over time, and highlight the need for a prognostic algorithm.Entrez PubMed



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